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causes hematology anemia deficiency hemolysis intravascular iron vasculitis acute aki classification enlarged fe ferritin glomerulonephritis injury monoclonal nephrology oncology paraproteinemias
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... Diagnosis Algorithm ... Differential #Diagnosis ... #Algorithm #Causes ... #Hematology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... (AKI) - Differential ... Vasculitis • GN ... Med, Contrast, Pigment ... #causes #algorithm
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Diagnosis Algorithm ... (not extravascular ... ) hemolysis, Intensive ... #Diagnosis #Algorithm ... #ferritin #hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... • Limited to Kidney ... #diagnosis #algorithm ... #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Diagnosis Algorithm ... Inflammatory • Systemic Lupus ... Serum Sickness Hemolytic ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Iron Deficiency - Differential ... Diagnosis Algorithm ... hemolysis, (PNH ... hepcidin: Chronic kidney ... #Fe #algorithm
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Coombs (-) hemolytic ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... inflammation Others: • Lupus ... such as systemic lupus ... Kidneys -> glomerulonephritis ... #diagnosis #rheumatology
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