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causes nephrology vasculitis acute aki ana antinuclear erythematosus hematology patterns systemic autoantibodies classification glomerulonephritis injury kidneyinjury mimickers polycythemia progressive proteinuria
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... • Limited to Kidney ... #diagnosis #algorithm ... #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus (SLE ... erythematosus (SLE ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology ... #diagnosis #differential
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... (AKI) - Differential ... Vasculitis • GN ... Med, Contrast, Pigment ... #causes #algorithm
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Proteinuria - Differential ... Diagnosis Algorithm ... • Anti-GBM antibodies ... (MPA) • SLE ... #Diagnosis #Algorithm
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
involvement 3% SLE-Related ... Auto-Antibodies ... Diagnosis and Lupus ... Lupusreference #SLE ... #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Diagnosis Algorithm ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA antibodies ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Causes of Acute Kidney ... Diagnosis Algorithm ... Acute Kidney Injury ... Glomerulonephritis • Anti-GBM antibodies ... #Diagnosis #Algorithm
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... C4) • ds-DNA: Kidney ... • Kidney biopsy ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... such as systemic lupus ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... #diagnosis #rheumatology
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