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diagnosis erythematosus sle systemic differential management vasculitis monoclonal oncology table activation algorithm antinuclear cerebritis cns comparison cryoglobulinemia cryoglobulins druginduced eularacr
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... pericarditis • Hematologic ... low C4, Low C3 and ... Erythematosus #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Auto-Antibodies: - ANA ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... Erythematosus #Diagnosis #autoantibodies ... #differential #rheumatology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... drugs, malignomas, and ... - systemic lupus ... dermatomyositis #Size #Classification ... Vessels #Diagnosis #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Cerebrovascular Disease ... the formation of autoantibodies ... Diagnosis of Lupus ... CNS #neurology #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... involvement: Anti-GBM Disease ... (C-ANCA): GPA > ... diagnosis #algorithm #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... macular Vasculitis) Autoantibodies ... to cold IgG • Lupus ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... with auto-immune diseases ... #Antinuclear #autoantibodies ... erythematosus #diagnosis #rheumatology ... #table #ANA
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... • Anti-Ro/SSA autoantibodies ... Non-autoimmune rheumatologic ... vein thrombosis Hematologic ... Erythematosus #Diagnosis #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... Workup: - ANA ... of autoantibodies ... Evolution: Chronic disease ... comparison #table #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... SJIA], systemic lupus ... Histopathologic criteria ... Diagnosis #Management #Hematology ... #Rheumatology
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