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diagnosis differential management antinuclear autoantibodies classification erythematosus syndrome systemic sle table associations diseases patterns treatment workup activation adultonset agglutinin algorithm
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... involvement: Anti-GBM Disease ... diagnosis #algorithm #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Associated Rheumatic Diseases ... #Antinuclear #Antibodies ... #ANA #patterns ... #rheumatology #diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... Vasculitis: • ... #diagnosis #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... ANA (anti-nuclear ... others (RNP, aPL antibodies ... Vasculitis: P-ANCA ... Autoantibodies #Rheumatology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Vasculitis of ... small vessels - ANCA-associated ... drugs, malignomas, and ... - systemic lupus ... Vessels #Diagnosis #Rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... , Drug-induced Lupus ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria ... low C4, Low C3 and ... Highly specific antibodies ... Classification #Criteria ... Erythematosus #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... Others: • Lupus ... LFT • ESR • ANA ... ) pattern: antibodies ... differential #diagnosis #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
ANA - Non-specific ... c-ANCA - Vasculitis ... - Vasculitis, e.g ... diagnosis #table #rheumatology ... #antibodies
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... Non-autoimmune rheumatologic ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies ... Erythematosus #Diagnosis #Rheumatology
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