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diagnosis differential management ana antinuclear erythematosus syndrome systemic autoantibodies classification sle arthritis patterns signs symptoms table treatment workup activation adultonset
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
- Kawasaki disease ... and infectious diseases ... - serum disease ... - systemic lupus ... Vessels #Diagnosis #Rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... involvement: Anti-GBM Disease ... diagnosis #algorithm #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... , Drug-induced Lupus ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
Onset Still's Disease ... - Malignant diseases ... - Inflammatory disease ... AdultOnset #Stills #Disease ... #Major #Minor #Rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
ANA ≠ Autoimmune Disease ... connective tissue disease ... • Rheumatic Diseases ... Non-Rheumatic Diseases ... ANA #patterns #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... connective tissue disease ... 90% • Anti-GBM disease ... #diagnosis #rheumatology ... #diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... (TTG) - Celiac disease ... #Associations #diseases ... diagnosis #table #rheumatology ... #antibodies
Seronegative Inflammatory Arthritis - Differential Diagnosis • Seronegative Rheumatoid Arthritis • Infectious Arthritis: Viral, Bacterial,
Systemic Rheumatic Disease ... : Systemic Lupus ... Sclerosis, Sjogren's Disease ... Sarcoidosis, Still's Disease ... Differential #Diagnosis #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... (RA), Systemic lupus ... Differential #Diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... atherosclerotic disease ... most important diseases ... differential #diagnosis #rheumatology
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