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diagnosis hematology anemia causes extravascular hemolysis intravascular agglutinin anemias autoimmune classification cold dermatology disease enlarged erythematosus glomerulonephritis monoclonal oncology paraproteinemias
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Diagnosis Algorithm ... Anemias (AIHAs) ... #Diagnosis #Algorithm ... #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... Extravascular #Differential ... #Diagnosis #Algorithm ... #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Autoimmune Hemolytic ... Anemia (AIHA) ... Autoimmune • Lupus ... Diagnosis #Differential ... #Algorithm
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
- Autoimmune (AIHA ... usually IgG) (e.g. lupus ... - Autoimmune (AIHA ... Extravascular #Causes #differential ... #diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... Coagulopathy) SMZL: • AIHA ... • Coombs (-) hemolytic ... to cold IgG • Lupus ... #Monoclonal #Differential
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... #differential # ... diagnosis #algorithm ... #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... cardiac valve, vasculitis ... #Anemia #Differential ... #workup #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Splenomegaly - Differential ... Diagnosis Algorithm ... Inflammatory • Systemic Lupus ... Serum Sickness Hemolytic ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Diagnosis Algorithm ... blood loss, Acute hemolysis ... , Vasculitides, ... #Diagnosis #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... rapidly progressing GN ... inflammation Others: • Lupus ... such as systemic lupus ... #rheumatology #
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