62 results
Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Erythematosus #SLE ... #hematology #rheumatology ... #differential # ... diagnosis #causes
Approach to managing Glomerulonephritis (GN) in children. 

ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
Glomerulonephritis (GN ... cytoplasmic antibodies ... ; SLE, systemic ... lupus erythematosus ... Glomerulonephritis #Algorithm
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... #Antinuclear #Antibodies ... #ANA #patterns ... #rheumatology #diagnosis ... #differential
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... #diagnosis #algorithm ... #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
- Differential ... Diagnosis Algorithm ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA antibodies ... #Causes #Hematology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... - Differential ... Diagnosis Algorithm ... • Anti-GBM antibodies ... (MPA) • SLE
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... others (RNP, aPL antibodies ... glycoprotein I (ß2GP), Lupus ... Autoantibodies #Rheumatology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Causes of Neutropenia ... Pancytopenia - Differential ... Diagnosis Algorithm ... and non-hematologic ... #Causes #Hematology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... #Antinuclear #Antibodies ... #rheumatology #diagnosis ... #differential
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Auto-Antibodies ... : - ANA 95-100% ... Diagnosis and Lupus ... Lupusreference #SLE ... #rheumatology