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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Microangiopathies #Systemic #Lupus ... Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis #causes
Seronegative Inflammatory Arthritis - Differential Diagnosis
 • Seronegative Rheumatoid Arthritis 
 • Infectious Arthritis: Viral, Bacterial,
Seronegative Inflammatory Arthritis ... • Infectious Arthritis ... Disease: Systemic Lupus ... , Reactive Arthritis ... #Diagnosis #rheumatology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
GCA), Takayasu's arteritis ... , Cogan's Syndrome ... (RA), Systemic lupus ... (SPA) • Other Causes ... Differential #Diagnosis #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... Pleuritis) H Hematologic ... cytopenias) A Arthritis ... sle #systemic #lupus ... erythematosus #rheumatology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm
Congenital
Medications
 • Anticonvulsants
 • Antibiotics
 • Antithyroid
 • Antihypertensive
Causes of Isolated ... • Epstein-Barr Virus ... Destruction • Systemic Lupus ... • Rheumatoid Arthritis ... #Hematology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Homogeneous: Systemic lupus ... , Drug-induced Lupus ... Juvenile Idiopathic Arthritis ... SLE), Sjogren's Syndrome ... ANA #patterns #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
GI - Felty syndrome ... • Felty's syndrome ... Shrinking lung syndrome ... , Marfan syndrome ... differential #diagnosis #rheumatology
Causes of Severe Aortic Regurgitation - Differential Diagnosis
Acute:
 • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Causes of Severe ... Inflammatory: Lupus ... , Behcet Syndrome ... Ehlers-Danlos Syndrome ... Differential #Diagnosis #Causes
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
• Gonococcal arthritis ... Antiphospholipid-antibody syndrome ... • Psoriatic arthritis ... lesions • Discoid lupus ... differential #diagnosis #rheumatology
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis
 • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Lemierre's syndrome ... Malignancy: - Hematologic ... . autoimmune): Lupus ... , Rheumatoid arthritis ... Vasculitis (Temporal arteritis