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diagnosis differential erythematosus sle systemic vasculitis myopathy rheumatoid antibodies antinuclear autoantibodies autoimmune classification comparison disease henochscholeinpurpura hsp iga laboratory management
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... Rheumatica • Pain ... with temporal arteritis ... and/or joint aches ... diagnosis #comparison #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
of hip (rare), Arthritis ... lesions Abdominal pain ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis ... noninflammatory Signs ... constitutional symptoms ... - Autoimmune Rheumatologic ... Joint #pain #Differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... anemia 4% - Myositis ... Auto-Antibodies: - ANA ... autoantibodies #signs ... #symptoms #mimickers
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
Rheumatoid Arthritis ... knees, shoulders Signs ... & Symptoms: • ... pain / swelling ... diagnosis #management #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... context of other symptoms ... Juvenile Idiopathic Arthritis ... Sjögren Syndrome, Myositis ... #patterns #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... • Progressive symptoms ... Palpable purpura, joint ... and GN Anti-GBM ... Differential #Diagnosis #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... Non-autoimmune rheumatologic ... : • Joint pain ... arthropathy • 90% joints ... : • Symptoms limited
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... vesicular eruption - Joints ... Presentation - Systemic Symptoms ... purpura: strong sign ... LFT • ESR • ANA
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Episcleritis Signs ... and Symptoms: ... pain of the joints ... (arthritis and ... ’s syndrome - Lupus
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