23 results
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Inflammatory and Autoimmune ... Diseases: • Systemic ... lupus erythematosus ... • Epstein-Barr virus ... Differential #Diagnosis #Hematology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Classification Criteria for Systemic ... • Arthritis domain ... pericarditis • Hematologic ... Thrombocytopenia, Autoimmune ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... Juvenile Idiopathic Arthritis ... Juvenile Idiopathic Arthritis ... Thyroid, Autoimmune ... ANA #patterns #rheumatology
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
RA: rheumatoid arthritis ... SLE : systemic ... lupus. ... #Differential #Comparison ... Table #Pulmonary #Rheumatology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... weakness, less systemic ... myositis, and arthritis ... after 2 years of treatment ... Myositis #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... of hip (rare), Arthritis ... Thrombocytopenia #Lupus ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms
Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
Systemic Lupus Erythematosus ... SLE) - Typical Signs ... , Arthralgia / arthritis ... #SLE #Signs #Symptoms ... #diagnosis #rheumatology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm
Congenital
Medications
 • Anticonvulsants
 • Antibiotics
 • Antithyroid
 • Antihypertensive
• Epstein-Barr Virus ... Destruction • Systemic ... Lupus Erythematosus ... • Rheumatoid Arthritis ... Algorithm #Causes #Hematology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... Lupusreference #SLE #Systemic ... autoantibodies #signs ... #differential #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lupus erythematosus ... lupus erythematosus ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology