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differential classification cryoglobulinemia management algorithm cryoglobulinemic erythematosus gammopathy oncology significance sle systemic types altered ams ana anca antibodies antibody antineutrophil
Lupus Nephritis Classification Algorithm #Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis ... Algorithm #Lupus ... Classification #Algorithm #diagnosis ... differential #types #rheumatology ... #nephrology #renal
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... Cryoglobulinemia Renal-centered ... , Type I cryo GN ... #Differential #Diagnosis ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... to cold IgG • Lupus ... vascular beds-renal ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Hypertension and Altered Mental Status (AMS) - Differential Diagnosis Framework Hypertension: • Hypertensive emergency • Hypertensive encephalopathy
- Differential Diagnosis ... : • Acute GN ... Autoimmune: • Vasculitis ... • Lupus • Polyarteritis ... crises Drug
Diagnosis of Cryoglobulinemia Vasculitis 1) Presence of cryoglobulin Circulating immunoglobulins that precipitate with cold temperature and dissolve
Diagnosis of Cryoglobulinemia ... Vasculitis 1 ... arterioles) MONOCLONAL ... arthritis • Renal ... #Diagnosis #Rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
Renal involvement in 35% of mixed cryoglobulinemia vasculitis Associated with : • Absence of skin
Renal involvement ... cryoglobulinemia vasculitis ... TerrierBen #Renal ... #Management #Rheumatology ... Cryoglobulinemic #Nephrology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Butterfly rash, Vasculitis ... Abdominal pain (20%) Renal ... signs #symptoms #diagnosis ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... pulmonary and renal ... such as systemic lupus ... • Urinalysis (Renal ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Composed of monoclonal ... Labs/Diagnosis: ... (e.g. systemic lupus ... Cryoglobulins #diagnosis ... classification #rheumatology
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