33 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... Juvenile Idiopathic Arthritis ... SLE), Sjogren's Syndrome ... ANA #patterns #rheumatology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
- Takayasu arteritis ... central nervous system ... - systemic ... lupus erythematosus ... Vessels #Diagnosis #Rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Juvenile Idiopathic Arthritis ... SLE), Sjogren's Syndrome ... : Lupus (SLE), Systemic ... , Sjögren Syndrome ... ANA #patterns #rheumatology
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
PSS: Sjogren syndrome ... RA: rheumatoid arthritis ... SLE : systemic ... lupus. ... Table #Pulmonary #Rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
of hip (rare), Arthritis ... Demyelinating syndromes ... pain (20%) Renal disease ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
GCA), Takayasu's arteritis ... , Cogan's Syndrome ... (RA), Systemic ... lupus erythematosus ... Differential #Diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... #Lupus #Erythematosus ... Summary #diagnosis #rheumatology ... #management
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... Wiskott-Aldrich syndrome ... and Autoimmune Diseases ... : • Systemic lupus ... • Epstein-Barr virus
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Systemic lupus ... idiopathic arthritis ... lupus erythematosus ... #Diagnosis #Management ... #Hematology #Rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... sclerosis, Still's disease ... autoantibodies #signs ... #differential #rheumatology