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diagnosis differential sle symptoms antinuclear vasculitis antibodies classification hematology autoantibodies causes mnemonic neurology patterns table activation anca antibody antineutrophil aortitis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’ ... and Clinical Findings ... like rheumatoid arthritis ... lupus erythematosus ... (SLE) Signs /
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
lupus erythematosus ... lupus erythematosus ... (SLE), Sjogren's ... Syndrome (SS), ... lupus erythematosus
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
lupus erythematosus ... lupus erythematosus ... (SLE), Sjogren's ... lupus erythematosus ... , Sjögren Syndrome
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
of hip (rare), Arthritis ... Demyelinating syndromes ... #erythematosus # ... signs #symptoms ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... heart block • Sjogren ... #Lupus #Erythematosus ... Summary #diagnosis #rheumatology ... #management
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
central nervous system ... disease - systemic ... lupus erythematosus ... disease - Sjögren ... Vessels #Diagnosis #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... dermatomyositis, Sjogren ... syndrome, and mixed ... lupus erythematosus ... #Lupus #Erythematosus
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Wiskott-Aldrich syndrome ... Inflammatory and ... Autoimmune Diseases: • Systemic ... lupus erythematosus ... • Epstein-Barr virus
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
autoimmune (RA, Sjogren's ... antiphospholipid syndrome ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... Ann Marie Kumfer
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... Auto-Antibodies: - ANA ... #Lupus #Erythematosus ... autoantibodies #signs
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