40 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... seen in 30—70% of cases ... Vasculitis: • ... Renal-limited vasculitis ... antibodies #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
rapidly progressing GN ... tract, and often causes ... such as systemic lupus ... purpura: strong sign ... differential #diagnosis #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... glycoprotein I (ß2GP), Lupus ... Vasculitis: P-ANCA ... Autoantibodies #Rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Rapidly progressing GN ... purpura: Strong sign ... • Pauci immune GN ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... Nodosa (PAN), ANCA ... associated vasculitis ... (RA), Systemic lupus ... Differential #Diagnosis #rheumatology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Emboli, Thrombosis, Vasculitis ... • GN: ANCA, Anti-GBM ... Diagnosis #nephrology #causes
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of Vasculitis ... Vasculitis of ... small vessels - ANCA-associated ... - systemic lupus ... Vessels #Diagnosis #Rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Workup: - ANA ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Hypertension and Altered Mental Status (AMS) - Differential Diagnosis Framework

Hypertension:
 • Hypertensive emergency
 • Hypertensive encephalopathy
Renal: • Acute GN ... Autoimmune: • Vasculitis ... • Lupus • Polyarteritis ... Scleroderma renal crises ... Differential #Diagnosis #causes