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diagnosis hematology algorithm neurology oncology apml arteritis dermatology differentiation encephalopathy gca gravis infancy infant mds myasthenia myelodysplastic nonpalpable palpable pediatrics
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential ... ): • Acute infection ... Myelodysplastic syndrome ... #hematology #secondary
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome ... #Platelets #Differential
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Myelofibrosis Infectious ... : • Acute or Chronic ... effect following treatment ... #Hematology
Causes of Sudden Unexpected Death in Infancy (SUDI) - Differential Diagnosis Algorithm Congenital Anomaly / Disorder: •
Causes of Sudden ... Infancy (SUDI) - Differential ... Accidental* Other: • Acute ... Sudden Infant Death Syndrome ... #Peds #Pediatrics
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... - APLS • Acute ... Infectious Purpura ... pneumoniae Vascular Fragility ... #rheumatology #
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... risk-stratification • Risks: infection ... transformation to acute ... #treatment #hematology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
life-threatening Differential ... aspiration and acute ... precipitated by: Drugs, infection ... immunosuppressants - Meds ... Gravis #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... initiation • Differential ... Diagnosis: Infection ... APML #diagnosis #management
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Reversible course Differential ... , ADEM, Acute toxic ... the underlying cause ... • Treatment of ... #diagnosis #management
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
very remarkable w/differential ... vasculitis vs infection ... them, but urgent rheumatology ... #GiantCell #arteritis ... Symptoms #Diagnosis #Management
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