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differential nephrology algorithm hematuria rheumatology urology acute aki injury rpgn blood hypertension indications management membranoproliferative nephritic nonglomerular progressive proteinuria prs
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
formation along glomerular ... Sjogren's, rheumatoid arthritis ... (Dense deposit disease ... glomerulopathy, radiation nephritis ... #diagnosis #renal
Causes of Hematuria - Glomerular vs Non-glomerular == Glomerular == - Glomerulonephritis - Thin basement membrane disease ==
- Glomerular vs ... Non-glomerular ... == Glomerular ... == - Glomerulonephritis ... == Non-glomerular
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
of kidney function ... with evidence of glomerular ... immune deposits in glomeruli ... post-infectious GN Anti-Glomerular ... #RPGN #Classification
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
- Small vessel vasculitis ... - TTP/HUS • Glomerular ... glomerulonephritis ... tubular necrosis (causes ... #diagnosis #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Post-strep GN, Lupus Nephritis ... • Limited to Kidney ... #diagnosis #algorithm
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
presenting with overt glomerular ... Cytomegalovirus; GBM = glomerular ... atypical HUS; MPGN ... Nephrocalcinosis causes ... #glomerular #proteinuria
Causes of Hematuria - Differential Diagnosis Renal: - Glomerular - IgA Nephropathy, Thin basement membrane, Alport syndrome,
Renal: - Glomerular ... syndrome, Other glomerulonephritis ... - Interstitial nephritis ... Medullary sponge kidney ... necrosis, Sickle cell disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... arthritis. (± glomerulonephritis ... - Skin, glomeruli ... : glomerular ischemia ... Kidneys -> glomerulonephritis
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
or dipstick) Glomerular ... of Glomerular Bleeding ... of glomerular hematuria ... Suggestive of glomerular ... disease Renal
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... clinical context and signs ... • Glomerulonephritis ... / Vasculits: ANCA ... • Interstitial nephritis
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