26 results
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
• Vitamin K deficiency ... • Factor VII deficiency ... elevated in: • Heparin ... Thromboplastin #laboratory ... #hematology #diagnosis
Shotgun Laboratory Testing for Severe Acute Livery Injury

https://www.journalofhospitalmedicine.com/jhospmed/article/143598/hospital-medicine/ammonia-levels-and-hepatic-encephalopathy-patients-known

#TWDFNR #Testing #Laboratory #LiverInjury #Diagnosis #Workup #Hepatology #EBM #ChoosingWisely
Shotgun Laboratory ... ammonia-levels-and-hepatic-encephalopathy-patients-known ... TWDFNR #Testing #Laboratory ... Diagnosis #Workup #Hepatology
Bayesian combination of 4T score with Heparin PF4 antibody titer to obtain the post-test probability of
4T score with Heparin ... PulmCrit #4TScore #Heparin ... Bayesian #Diagnosis #Hematology ... Thrombocytopenia #Laboratory
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Hemophilia A - Deficiency ... Medications - Heparin ... • Acute DIC - Septic ... comparison #diagnosis #hematology ... #deficiency
Iron Panel Interpretation

Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation,  ↓
Interpretation Iron deficiency ... Ferritin Iron deficiency ... Interpretation #deficiency ... #differential #hematology ... #laboratory
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... Findings in Hepatic ... thrombopoietin deficiency ... #LiverFailure #Hepatic ... #Hepatology #Laboratory
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
clotting factor deficiency ... Patient has a factor deficiency ... Study #diagnosis #hematology ... pathophysiology #hematology ... #laboratory
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
single factor deficiency ... severe fibrinogen deficiency ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... #differential #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Acquired deficiency ... unfractionated heparin ... cause e.g. heparin ... thrombin inhibitors, heparin ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
venipuncture sites Laboratory ... thrombopoietin deficiency ... ) • HIT: Heparin-PF4 ... 100mg/dL) - Heparin ... treatment #management #hematology