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diagnosis differential management rheumatology algorithm causes hepatology treatment anemia blood cirrhosis dermatology immunology product reactions signs symptoms thrombocytopenia agammaglobulinemia alkaline
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Protein S deficiency ... - Protein C deficiency ... - Antithrombin deficiency ... #pathophysiology ... #hematology #differential
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
C5-C9 Deficiency ... higher in C5-C9 deficiency ... population • C5-C9 deficient ... cell C5-C9 deficiency ... C5C9Deficiency #Complement #pathophysiology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency ... Bypass surgery, Bacterial ... Zinc excess or deficiency ... , Copper deficiency ... Algorithm #ferritin #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... Acute hemolysis, deficiency ... infections, TB, Acute bacterial ... Diagnosis #Algorithm #hematology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
clotting factor deficiency ... Patient has a factor deficiency ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... Stroke Volume / Arterial ... less compliant arteries ... • Severe iron deficiency ... Differential #Diagnosis #Pathophysiology
Non-cirrhotic Hyperammonemia - Differential Diagnosis Framework Hematologic & Vascular: • Multiple myeloma & Acute leukemia (plasma cells
Diagnosis Framework Hematologic ... Defects • OTC deficiency ... (XLR) • Deficiency ... Differential #Diagnosis #Pathophysiology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
necrosis) • VIT K deficiency ... gangrenosum • Bacterial ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
Protein C & S deficiency ... , ATIII deficiency ... anti-coagulation • Hematologic ... upstream CRAO -> Arteriole ... Occlusion #CRAO #pathophysiology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Spoon-shaped • Iron deficiency ... usually painful • Bacterial ... Systemic #Secondary #dermatology
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