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diagnosis differential rheumatology algorithm causes management clinical dermatology nephrology signs neurology pulmonary symptoms treatment disease pathophysiology hematology classification lupus workup
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Anti-GBM Disease (Goodpasture's ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA, ... Glomerulonephritis #Vasculitis
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
vasculitis (Eosinophilic ... vasculitis (IgA-associated ... vasculitis, Behcet ... Basement Membrane: Goodpasture's ... testing: anti-ANCA
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Graves' disease c-ANCA ... - Vasculitis, e.g ... granulomatosis p-ANCA ... - Vasculitis, e.g ... disease Anti-GBM - Goodpasture's
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of Vasculitis ... Vasculitis of ... small vessels - ANCA-associated ... vasculitis ... hepatitis C - Goodpasture
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... vasculitis (AAV ... Anti-basement membrane: Goodpasture ... palpable purpura 2/2 vasculitis ... Auto-antibodies: ANCA
Hemoptysis - Differential Diagnosis Framework Massive Hemoptysis: >150-300 mL in 24h Airway disease: • Bronchitis, Bronchiectasis, Malignancy
/ Autoimmune: ANCA-Assoc ... vasculitis (GPA ... Cryoglobulinemia, Goodpasture's
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
Vasculitis A group ... , small-vessel vasculitis ... Levamisole-induced vasculitis ... vasculitis - MPO ... #Associated #Vasculitis
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... Diagnosis #IM #Rheum #Vasculitis ... Classification #ANCA
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: ANCA Associated ... - ANCA specific ... Granulomas - ANCA ... Granulomas - ANCA ... Vasculitis: + MPO-ANCA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... Vasculitis: • ... 80-90%) > MPO - ANCA ... Renal-limited vasculitis ... Antinuclear #Antibody #ANCA
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