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diagnosis differential workup anemia hemolytic pancytopenia agglutinin antiphospholipid apls champs cold compared comparison deficiency disease disorders eosinophil eosinophilia erythemas extravascular
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... methotrexate) • Drugs Autoimmune ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Differential Diagnosis Algorithm ... Cold AIHA • Alloimmune ... perfringens - Complement-Mediated ... #Causes #Hematology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Atypical HUS, autoimmune ... Hypocomplementemia #Low #Complement ... #differential #hematology
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... suspicion for complement ... #Deficiency #Testing ... #Algorithm #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... Autoimmune Mediated ... Autoimmune condition ... Eating disorders ... #Hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Algorithm INDICATIONS ... for secondary causes ... eosinophilia (common causes ... Eosinophil #Disorders #Algorithm ... Differential #diagnosis #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... Autoimmune Mediated ... Autoimmune condition ... Eating disorders ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... elliptocytosis, autoimmune ... Differential #Diagnosis #Algorithm ... #workup #hematology ... #testing
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... is due to TTP, compliment-mediated ... . 5. 2nd TMA- autoimmune ... Microangiopathy #TMAs #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... Positive Coombs testing ... CLL (older) • Autoimmune ... temperatures by fixing complement ... hemolytic #anemia #hematology
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