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differential management causes hematology treatment workup criticalcare mass cardiology ddxof nephrology hepatology pulmonary dermatology disease disorders endocrinology evaluation lymphohistiocytosis primarycare
Proposed Treatment Algorithm for MAS / HLH #MAS #HLH #Hemophagocytic #Lymphohistiocytosis #Management #Treatment #Algorithm #Hematology
Proposed Treatment Algorithm ... for MAS / HLH ... #MAS #HLH #Hemophagocytic ... Management #Treatment #Algorithm
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Hemophagocytic Lymphohistiocytosis ... IL-2 receptor Diagnostic ... Criteria): Molecular diagnosis ... #Hemophagocytic ... Lymphohistiocytosis #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... Auto-amplification loop Diagnosis ... Chediak-Higashi, Griscelli, Purtilo ... #Hemophagocytic ... Lymphohistiocytosis #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... Presentation / Diagnosis ... It presents as an ... Diagnosis via genetic ... #Hemophagocytic
Diagnostic Schema for Hyperferritinemia Pearl: Diseases associated with extreme elevations: 1. HLH 2. Still's disease 3. Systemic
Diagnostic Schema ... HLH 2. ... Hyperferritinemia #Algorithm ... #Differential #Diagnosis
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
and Differential Diagnosis ... Algorithm Consumption ... and Screen for HLH ... HLH syndrome 5. ... • Hypoplastic MDS
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Activation Syndrome (MAS ... A subset of hemophagocytic ... lymphohistiocytosis (HLH ... hypersensitivity syndromes • HLH ... Activation #Syndrome #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... (HLH) Treatment ... Primary HLH: - ... underlying condition may ... #Hemophagocytic
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
and Differential Diagnosis ... Algorithm Consumption ... and Screen for HLH ... HLH syndrome 5 ... • Hypoplastic MDS
Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Criteria - 2004 vs 2009 At least three of the following: -
Hemophagocytic Lymphohistiocytosis ... (HLH) Diagnostic ... @PulmCrit #HLH ... #Hemophagocytic ... Lymphohistiocytosis #Diagnosis
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