79 results
Kaposi Sarcoma Herpes Virus (KSHV)

By Dr. Sara Dong @swinndong via #IDFellowCase
#ID  #Infectious Diseases  #Infections
#Differential
ID #Infectious Diseases ... Diagnosis #KSHV #HHV ... lymphoproliferative #KICS
Clinical Manifestations of Human Herpes Viruses (HHV)

Herpes simplex virus 1	HSV-1	Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Herpes Viruses (HHV ... Mononucleosis-like disease ... herpes virus 6 HHV ... herpes virus 7 HHV ... Herpes #Viruses #HHV
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation
Kaposi sarcoma (KS):
 • Target organs: Ubiquitous (cutaneous and mucosal
HHV8/KSHV-reIated ... diseases: From ... Light chain: - HHV8 ... de Fremont #HHV8 ... #diseases #comparison
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... • unicentric, HHV8 ... with Castleman's disease ... Plasmablastic subtype is HHV8 ... myeloma, POEMS) HHV8
KSHV Inflammatory Cytokine Syndrome (KICS)

By Dr. Sara Dong @swinndong  via #IDFellowCase
#ID  #Infectious Diseases
Cytokine Syndrome (KICS ... ID #Infectious Diseases ... Diagnosis #KSHV #HHV ... #KICS #Kaposi
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... borrelia, Rubeola, HBV ... Coxsackie, CMV, EBV, HIV ... autoinflammatory diseases ... management #treatment #rheumatology
KSHV Inflammatory Cytokine Syndrome (KICS)
Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
Cytokine Syndrome (KICS ... Definition for KICS ... KSHV-multicentric Castleman disease ... Infectious Diseases ... diagnosis #management #hhv8
IDSA Recommendations for Preventing and Treating HHV-8 Diseases—Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL), Multicentric Castleman’s
Preventing and Treating HHV ... -8 Diseases—Kaposi ... lifethreatening disease ... activity against HHV ... adjunctive therapy #HHV8
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
reaction - Atopic disease ... lymphomas, Hodgkin disease ... aspergillosis - Viral ... infections (HIV ... , IgG4-related disease
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... CTD (SLE) - Viral ... Von Willebrand disease ... • HCV, HBV Not ... #rheumatology #