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differential management oncology disorders leukemia product transfusion workup anemia aplastic cancer chronic cll coagulation comparison dic disseminated eosinophil eosinophilia intravascular
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... : Acute blood loss ... Rebound effect from treatment ... to Medications: ... #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... disorders • Celiac disease ... effect following treatment ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... family history - Medications ... plateletcount), peripheral blood ... test, ANA (e.g., SLE ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... : - Thrombocytopenia ... fever • Drug reactions ... #hematology #rheumatology ... #nonpalpable #dermatology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Peripheral blood ... allergy, drug reaction ... glucocorticoid treatment ... #Differential #diagnosis ... #hematology #eosinophilia
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Risk factors: Critical ... of high parity blood ... Pathophysiology: 2 hit ... without other cause ... #hematology #diagnosis
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... severe thrombocytopenia ... TRALI): Leading cause ... #Transfusion #diagnosis ... #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... organ damage Clinical ... • Severe Liver Disease ... #causes #treatment ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... severe thrombocytopenia ... TRALI): Leading cause ... #Transfusions #diagnosis ... #management #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... and petechiae Causes ... result from low blood ... Anemia #oncology #hematology ... #diagnosis #management
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