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diagnosis management algorithm oncology pathophysiology product reactions rheumatology aflp aplastic calculation classification dermatology disorders elevatedmcv embolism fatty hemophagocytic hlh hodgkins
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
disease, Acute blood ... : Alcohol use, Liver ... #differential # ... diagnosis #causes ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... ) - Differential ... Algorithm Normal Blood ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
plateletcount), peripheral blood ... : INR/PT, aPTT(liver ... changes), high MCV ... anemia (vegan, ... #Workup #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... : Acute blood loss ... hemolysis, deficiency anemia ... Malignancy: Metastatic cancer ... Diagnosis #Algorithm #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
= (Retic %) x (Hct ... the peripheral blood ... infiltration (e.g. cancer ... Production #Index #hematology ... #anemia #differential
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Thrombosis - Differential ... Syndrome, Ischemic Liver ... , IBD • COVID- ... coagulation and other causes ... pathophysiology #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... - EBV - CMV ... result from low blood ... • Allogeneic HSCT ... #oncology #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... - Hemolytic anemia ... deficiency • Liver ... • HCV, HBV Not ... #Diagnosis #hematology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
AP, ↑INR, ↑BUN/Cr ... ↓Antithrombin Ill ... infiltration) Differential ... transplant center ... #Pregnancy #hepatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... cytokines (TNFa,lL1, IL6 ... B-LNH), solid cancers ... Drugs, Unknown cause ... PTLD), allogeneic HSCT
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