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Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • ... Diagnosis #Algorithm #Causes
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
a.k.a. cardiorenal syndrome ... a.k.a. hepatorenal syndrome ... vasculitis - TTP/HUS ... tubular necrosis (causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
• Secondary Causes ... disease - DIC/TTP/HUS ... Kasabach-Merritt syndrome ... : • DIC, TTP/HUS ... Gardner-Diamond syndrome
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... antiphospholipid syndrome
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... (HUS) • Other ... Extravascular #Causes
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Microangiopathy: DIC, TTP, HUS ... antiphospholipid syndrome
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
osmolarity If cause ... Abdominal compartment syndrome ... pressure • TTP / HUS ... • Cardio-renal syndrome ... Diagnosis #nephrology #causes
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
glomerulonephritis; HUS ... hemolytic-uremic syndrome ... HUS; MPGN = membranoproliferative ... Nephrocalcinosis causes ... proteinuria #nephrotic #syndrome
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... • Hepatorenal syndromes ... Epithelial cell casts ... Ethylene glycol) TTP/HUS ... Diagnosis #Algorithm #Causes
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cryoglobulins • Negative causes ... Cryoglobulinemia • TTP, HUS ... Antiphospholipid syndrome
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