21 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... EBV, CMV), Alcohol-related ... liver disease, ... e.g. ascites), Chronic ... hepatitis fibrosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... disease, liver ... Failure Infections Alcohol-Associated ... Injury (DILI)
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... disease 6-9 mo ... gastroenterology #hepatology
Here is a quick guide on the common direct-acting antivirals (DAAs) for chronic hepatitis C virus
antivirals (DAAs) for chronic ... DAAs #Antivirals #table ... #treatment #hcv ... infectiousdisease #hepatology ... #Management #Pharmacology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
• Iatrogenic: DILI ... ALT Ratios: • Alcoholic ... liver disease: ... > 2 • NASH, Chronic ... injury: > 3 • Chronic
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... 5-10x normal - Chronic ... normal - Hemolysis, NASH ... #Injury #hepatology ... #LFTs #transaminitis
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... HAV immunity; Liver ... Chronic Hepatitis ... #HepatitisB #HBV ... #Treatment #Hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... ALT Ratios: • Alcoholic ... liver disease: ... > 2 • NASH, Chronic ... transaminitis #LFTs
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... D/E, EBV, CMV, HSV ... Drugs (MDMA), Alcohol ... Transaminitis #LFTs ... #hepatitis
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
arthritis, Skin rash ... borrelia, Rubeola, HBV ... hepatomegaly, hepatitis ... #diagnosis #management ... #treatment #rheumatology