13 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... for alternative causes ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... #Algorithm #hepatology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Pregnancy - TTP/HUS ... , HELLP Syndrome ... child * Severe cases ... AFLP #obstetrics #hematology ... #diagnosis #table
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular Causes ... • Pregnancy: HELLP ... , Chronic viral ... diagnosis #algorithm #hepatology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
coagulation defects. 1) HELLP ... child * Severe cases ... Pregnancy #TTPHUS #HELLP ... Obstetrics #OBGyn #Hematology ... Diagnosis #Comparison #Table
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... , D, EBV, CMV, HSV ... biliary obstruction, HELLP ... Acute #algorithm #hepatology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Anemia Intrinsic Causes ... : • Liver disease ... • MAHA: TTP, HUS ... , DIC, HELLP, AS ... classification #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
hepatitis serologies, HCV ... disease: > 2 • NASH ... , Chronic viral ... : > 3 • Chronic ... #differential #Hepatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... • Evolution: Chronic ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... disease • Liver ... DDX - Other causes ... Malignancies • Chronic ... hypogammaglobulinemia #immunology #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
DIC • Severe Liver ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management ... #hematology