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diagnosis algorithm arterial embolism erythematosus framework hemolysis hypercoagulable hypocomplementemia low lupus mnemonic nonpalpable palpable pathophysiology purpura schistocytes sle systemic thrombocytopenia
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
RA, Sjogren's), antiphospholipid ... syndrome, atheroembolic ... subacute bacterial endocarditis ... #diagnosis #differential ... #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... hemolytic-uremic syndrome ... (ST-HUS) - Complement-mediated ... • Catastrophic APLS ... #diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Thrombocytopenia - Differential ... Autoimmune: SLE, RA, antiphospholipid ... syndrome - Pregnancy ... valve replacement, endocarditis ... Diagnosis #Framework #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- PNH - APLS ... • Bacterial endocarditis ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Nephrotic Syndrome ... Malignancy - Antiphospholipid ... antibodies (APLS ... pathophysiology #hematology ... #differential #
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid ... Syndrome (APLS) ... Hypercoagulable Workup ... #Antiphospholipid ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... • Libman-Sacks endocarditis ... Erythematosus #Diagnosis #Rheumatology
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