Haglund syndrome rheumatology workup ucl autoantibodies diseases systemic disease antibodies antibody antinuclear table monoclonal phenotypes erythematosus rheumatoid anca

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ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

ANA (Antinuclear ... connective tissue disease ... 90% • Anti-GBM disease ... #Antinuclear #Antibody ... diseases

Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA

their Disease Associations ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases ... antibodies

Autoantibodies in Rheumatology
• Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and

Autoantibodies in ... others (RNP, aPL antibodies ... ribonucleoprotein) • RA: Rheumatoid ... • Scleroderma (Systemic ... #associations #table

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... Antibody refers ... • Rheumatic Diseases ... #Antibodies #ANA ... #patterns #rheumatology

ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

Associated Rheumatic ... Diseases: • Homogeneous ... connective tissue disease ... SLE), Sjogren's Syndrome ... #Antibodies #ANA

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

Decade Skin Disease ... diseases (i.e. ... (e.g. thyroid disease ... ) • Kikuchi disease ... • Castleman's disease

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... Association with disease ... with auto-immune diseases ... #autoantibodies ... #table #ANA

Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of

Rheumatology Workup ... Diseases • Septic ... exclude inflammatory disease ... connective-tissue disease ... #Disease #Rheumatoid

Cryoglobulinemia Summary

Cryoglobulins:
• Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below

• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... lupus erythematosus ... classification #rheumatology

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