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diagnosis antinuclear lupus associations differential erythematosus management sle antibody antineutrophil comparison druginduced myopathy myositis patterns sjogrens
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... their Disease Associations ... ANA - Non-specific ... c-ANCA - Vasculitis ... granulomatosis p-ANCA
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ANA ... others (RNP, aPL antibodies ... • Scleroderma (Systemic ... : P-ANCA (perinuclear ... #associations #table
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
cases • Sjögren syndrome ... connective tissue disease ... 90% • Anti-GBM disease ... Jcortesizaguirr #ANA ... #diseases
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... Disease! ... Rheumatic Diseases ... • Rheumatic Diseases ... #rheumatology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Diagnosis: • ANCA-associated ... tissue disease ... rheumatologic diseases ... Serositis Labs: • ANA ... • (-) ANA + (+
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... associated with other diseases ... demyelinating disease ... peripheral Thyroid Disease ... Tracheobronchial disease
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
and Systemic lupus ... Association with disease ... searched for when ANA ... with auto-immune diseases ... #table #ANA
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
: - ANA > ... of autoantibodies ... : - ANA > ... Evolution: Chronic disease ... #rheumatology #
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Interstitial lung disease ... (ANA present 80% ... Interstitial lung disease ... Interstitial lung disease ... skeletal muscle disease
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