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differential erythematosus sle hematology management vasculitis antinuclear associations autoimmune chronic classification comparison dermatology druginduced leukemia lymphocytic mimickers monoclonal myopathy myositis
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ANA ... • Scleroderma (Systemic ... Ill • ANCA Vasculitis ... : P-ANCA (perinuclear ... #table
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Auto-Antibodies: - ANA ... and Lupus Mimickers ... #Diagnosis #autoantibodies ... #signs #symptoms
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
: - ANA > ... of autoantibodies ... : - ANA > ... #rheumatology # ... diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... findings (ANA, ... Serositis Labs: • ANA ... antibodies • (-) ANA ... #Diagnosis #Rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Systemic lupus ... searched for when ANA ... #Systemic #lupus ... #rheumatology # ... table #ANA
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Others: • Lupus ... as systemic lupus ... Symptoms (Sx) in ... purpura: strong sign ... #rheumatology #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... cells can indicate disease ... #workup #oncology ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
macular Vasculitis) Autoantibodies ... Evans • ITP • Cl-NH ... to cold IgG • Lupus ... #Differential #Diagnosis ... #Oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Symptoms (SX) in ... purpura: Strong sign ... CRP GCA (Giant Cell ... • Progressive symptoms ... #Rheumatology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
disease. ... Episcleritis Signs ... and Symptoms: ... - Lupus - Leukemia ... #oncology
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