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diagnosis antibodies antibody antineutrophil antinuclear aortitis associations autoimmune classification conditions erythematosus extrarticular hematology lupus monoclonal myopathy myositis oncology pain paraproteinemias
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... their Disease Associations ... ANA - Non-specific ... c-ANCA - Vasculitis ... granulomatosis p-ANCA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
cases • Sjögren syndrome ... connective tissue disease ... 90% • Anti-GBM disease ... Jcortesizaguirr #ANA ... #diseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... most important diseases
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
arteritis, Cogan's Syndrome ... polychondritis, Behcet's Disease ... Nodosa (PAN), ANCA ... ) • Rheumatic Diseases ... : IgG4-Related Disease
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... diseases, such ... atherosclerotic disease ... most important diseases ... (GRANULOMATOUS DISEASE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... Decade Skin Disease ... tissue disease ... diseases (i.e. ... Serositis Labs: • ANA
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... Scleromyxedema (CNS+GI+CVS+joints ... ) Autoantibodies ... Sneddon-Wilkinson disease ... #Monoclonal #Differential
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
IBD, Whipple's disease ... • Whipple's disease ... , Vasculitis (e.g ... #pain #differential ... #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Interstitial lung disease ... -1 antibodies (ANA ... Interstitial lung disease ... or head drop • ANA ... skeletal muscle disease
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