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ana antibodies antinuclear erythematosus sle antibody antineutrophil aortitis arthritis autoimmune classification conditions dermatology hematology laboratory monoclonal myopathy myositis oncology paraproteinemias
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
lupus erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... #rheumatology # ... diseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• Kawasaki Disease ... (Granulomatous disease ... Diagnosis: Systemic ... rheumatic diseases ... differential #diagnosis
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... ), ANCA associated ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... #Diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Disease! ... • Rheumatic Diseases ... : Lupus (SLE), Systemic ... #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Decade Skin Disease ... Diagnosis: • ANCA-associated ... diseases (i.e. ... #Diagnosis #Rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
infection • Lyme disease ... migrans • Lyme disease ... Sarcoidosis • Crohn's disease ... #differential # ... diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... Demyelinating syndromes ... lesions Abdominal pain ... (20%) Renal disease ... #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... diseases, such ... atherosclerotic disease ... #Differential #Diagnosis
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
IBD, Whipple's disease ... , Vasculitis (e.g ... arteritis #Extrarticular ... #pain #differential ... #diagnosis #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... ) Autoantibodies ... to cold IgG • Lupus ... Sneddon-Wilkinson disease ... #Diagnosis #Oncology
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