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diagnosis differential hepatology causes transaminitis hepatitis neurology abnormal acute chemistry dili drug enzymes gastroenterology hepatocellular hepatorenal hrs htn hypertension idiosyncratic
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... normal - Hemolysis, NASH ... #Injury #hepatology ... #LFTs #transaminitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... Chronic - ongoing ↑ LFTs ... gastroenterology #algorithm ... gastroenterology #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... disease: > 2 • NASH ... • Gilbert's syndrome ... #differential #Hepatology ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... obstruction, HELLP Syndrome ... #Injury #Differential ... Causes #Acute #algorithm ... #hepatology
Causes of Seizures - Differential Diagnosis Algorithm Unprovoked - Epilepsy: • Focal: Simple, Complex • Generalized: Absence,
Differential Diagnosis Algorithm ... vasoconstriction syndrome ... Traumatic brain injury ... Hypoxia, Uremia, Liver ... #Causes #neurology
Secondary Causes of Hypertension - Differential Diagnosis Algorithm Hypertension - BP > 140/90 (>130/80 for DM) Hypertensive urgency
Differential Diagnosis Algorithm ... with end-organ damage ... • Bilateral RAS ... • Unilateral RAS ... HTN #Secondary #Nephrology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... tests algorithm ... presence of metabolic syndrome ... #LFTs #Abnormal ... #Algorithm #Hepatology
Mechanisms of Pain Mixed - Nociceptive/Neuropathic Nociceptive - Tissue Damage - Visceral - (From organ/cavity lining) Poorly localized,
Nociceptive - Tissue Damage ... regional pain syndrome ... • Spinal injury ... Pain #Mechanisms #Neurology ... Differential #Diagnosis #Algorithm
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