21 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... - infiltrates (anemia ... ) CLL Symptoms: ... (CLL) and/or Small ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... • Neutropenia, anemia ... microglobulin Treatment ... #diagnosis #workup ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
of anemia or thrombocytopenia ... lymphadenopathy and ... marrow failure with anemia ... #oncology #hematology ... hemeonc #diagnosis #management
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia
Induction: 
 • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate
Consolidation
Lymphoblastic Leukemia ... Cytarabine #ALL ... Lymphoblastic #Leukemia ... #oncology #pediatrics ... #peds #management
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
symptoms: • Recurrent ... Treatment: • Consider ... to MDS or acute leukemia ... #diagnosis #management ... #treatment #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... transformation to acute leukemia ... only curative treatment ... #treatment #hematology ... #oncology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
virus (EBV) • Leukemia ... Treatment: ... • Improve the symptoms ... #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... involve one, two, or all ... Workup: • Complete ... #oncology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
pylori test (GI symptoms ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... not required in all ... #hematology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... full infectious work-up ... days → add fungal work-up ... Usually myeloid leukemias ... (~20 %) and APL