29 results
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
- Differential ... Diagnosis Algorithm ... Sequestration: • Splenomegaly ... Toxins • Aplastic Anemia ... #Causes #Hematology
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Pancytopenia - Differential ... < 1800/uL, • platelet ... sequestration (splenomegaly ... MatthewHoMD #Pancytopenia ... #hematology #workup
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Thrombocytopenia ... myelofibrosis and splenomegaly ... Defects #comparison #table ... #differential # ... diagnosis #hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Diagnosis Algorithm ... lymphadenopathy, petechiae, splenomegaly ... hepatomegaly • Labs: anemia ... , ↑ MCV, ↑/↓ platelets ... #hematology #WBC
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... - Splenomegaly ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential ... Diagnosis and Workup ... changes), high MCV anemia ... ITP, unexplained pancytopenia ... #Workup #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Count - Differential ... → Refer to hematology ... hemolysis, deficiency anemia ... Vasculitides, IBD, Celiac disease ... #hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... Diagnosis Congenital ... Diseases: • GATA2 ... deficiency • Fanconi’s anemia ... Diagnosis #Hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
(AIHA) - Differential ... Diagnosis Table ... Cold Agglutinin Disease ... #Diagnosis #Table ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Diagnosis Algorithm ... disorders • Celiac disease ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Causes #Hematology