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diagnosis differential liver causes hematology injury jaundice transaminitis aflp anemias bilirubinemia chemistry classification comparison disease hellp hyperbilirubinemia icp interpretation isolated
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... - Differential ... Diagnosis Algorithm ... of anemia and hemolysis ... #hematology
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... Diagnosis Algorithm ... Production • Hemolysis ... Erythropoiesis • Hematoma ... #Causes #Hepatology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
production (eg, hemolytic ... anemias, hemolytic ... reactions, hematoma ... hepatocyte damage (eg, hepatitis ... differential #causes
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
, Toxic Hepatitis ... 2-5x normal - Hemolysis ... Liver #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Isolated Hyperbilirubinemia - Differential Diagnosis Algorithm Direct Hyperbilirubinemia: Dubin-Johnson Syndrome, Rotor Syndrome Indirect Hyperbilirubinemia: - Trauma, Hematoma,
Hyperbilirubinemia - Differential ... Diagnosis Algorithm ... Hyperbilirubinemia: - Trauma, Hematoma ... Count Abnormal: Hemolysis ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin: RBC (hemolysis ... , bleeding, hematoma ... LDH: Heart, RBC (hemolysis ... Gilbert's syndrome • Hemolysis ... #Hepatology #transaminitis
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Diagnosis Algorithm ... reticulocyte count, LFTs ... ↑ Destruction (hemolysis ... #Diagnosis #Algorithm ... #hematology #workup
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Gilbert's syndrome • Hemolysis ... Bilirubin: RBC (hemolysis ... , bleeding, hematoma ... LDH: Heart, RBC (hemolysis ... #hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
HELLP Syndrome (Hemolysis ... clinical features: Hemolysis ... Hepatic infarcts, Hematomas ... #obstetrics #hepatitis ... #comparison #differential
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