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Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
LFTs) - Causes of Hepatocellular ... Cholestatic Liver Injury ... Hepatocellular ... Liver Injury ... injury R
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury - Differential ... Framework: Liver Injury ... Liver Injury Differential ... #Liver #Injury
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Indirect (Hemolytic) Hepatocellular ... ALP) ≥5: Hepatocellular ... injury >2 ... 2: Cholestatic injury
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
of Acute Liver Injury ... Differential Diagnosis Hepatocellular ... Celiac Disease Hepatocellular ... Sophia_Hayes_MD #Liver #Injury
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... of Acute Liver Injury ... Thrombosis, Emboli Hepatocellular ... Infiltrative Labs in Hepatocellular ... ALP: Typical of hepatocellular
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Drug-induced Liver Injury ... dose dependent injury ... Calculate R-Value • Hepatocellular ... induced #Liver #Injury
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
ALP) • R > 5: Hepatocellular ... ALF): • Liver injury ... Cellular Destruction: Hepatocellular ... ALP: Typical of hepatocellular ... injury • Bilirubin
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Hepatocellular injury ... Hepatocellular Injury
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Induced Liver Injury ... involvement, Kidney injury ... alternative causes • Hepatocellular ... DrugInduced #Liver #Injury
Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
chain and inhibits hepatocellular ... and acute kidney injury
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