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Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
nonalcoholic fatty liver ... disease (NAFLD) ... specimens: ballooned hepatocytes ... cirrhosis, and primary liver ... Epidemiology #NASH #NAFLD
NAFLD Activity Score (NAS) 0–3 for steatosis 0–3 for inflammation 0–2 for ballooning hepatocytes NAS ≥5 is classified as definitive
NAFLD Activity Score ... for ballooning hepatocytes ... a simple fatty liver ... .2020.603926 #NAFLD
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... Synthesis: in hepatocyte
NAFLD / NASH Progression Timeline Healthy Liver → NAFLD/NASH → 0.25-3.2%/year → Cirrhotic NASH → 0.3-2.6%/year →
NAFLD / NASH Progression ... Timeline Healthy Liver ... → NAFLD/NASH → ... /year → HCC • NAFLD ... Polymorphisms, Age #NAFLD
Non-alcoholic fatty liver disease algorithm. For those patients with NAFLD or liver disease of unknown aetiology,
Non-alcoholic fatty liver ... patients with NAFLD ... or liver disease ... likelihood of liver ... ELF, enhanced liver
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... #GI #IM #NASH #NAFLD
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... 100-500): • NAFLD ... (Drug-induced liver ... Hepatopathy (shock liver ... LouLectures #Liver
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Hemochromatosis • NAFLD ... ALT < 5x ULN • NAFLD
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Wilson's, HH, NAFLD ... 5x ULN - NAFLD
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute Liver ... Hepatocellular - Liver ... Antitrypsin • Other: NAFLD ... Artery: Shock Liver ... Sophia_Hayes_MD #Liver
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