38 results
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte ... #Pathophys #Honc
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... Pathophysiology #GI
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
the extent of hepatocyte ... #Pathophys #Toxicology
Cutaneous and Systemic Findings in Dermatomyositis
Cutaneous Findings:
 - Heliotrope sign and edema
 - Nail-fold changes
 -
- Heliotrope sign ... or shawl sign ... - Gottron's sign ... scale - Holster sign ... vasculopathy of the GI
Pathyophysiology - hyperglycemic crises in patients with diabetes 
Key signs/symptoms of HHS/DKA:
Both: Polyuria, polydipsia, weight loss,
diabetes Key signs ... coma, seizure) #Pathophys
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
Leukemia) • GI ... pathophysiology #signs
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... • persistent GI ... phase symptoms Signs ... immunology #diagnosis #signs
Opportunistic Infections in HIV/AIDS
Here's a little symptom-based guide to OIs in pts with HIV I made
- Pulmonary - GI ... Guide #Symptoms #Signs
Hypothyroidism and Hyperthyroidism - Symptoms and Signs
Hypothyroidism:
 - General - From asymptomatic to myxedema coma, “Like
- Symptoms and Signs ... hypertension - GI ... Palpitations, Afib - GI ... Hyperthyroid #Symptoms #Signs
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
leaving enterocytes, hepatocytes ... cause increased GI