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Causes of Hepatomegaly and Splenomegaly in children

#Hepatomegaly #Splenomegaly #Hepatosplenomegaly #HSM #Differential #Causes #Peds #Pediatrics
Causes of Hepatomegaly ... in children #Hepatomegaly
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hepatomegaly - Differential ... Cirrhosis #Hepatomegaly
Right Sided Heart Failure Mnemonic: "AW HEAD"
ANOREXIA & NAUSEA 

WEIGHT GAIN 

HEPATOMEGALY 

EDEMA (BIPEDAL) 

ASCITES 

DISTENDED
WEIGHT GAIN HEPATOMEGALY
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
jaundice and tender hepatomegaly ... onset RUQ pain, hepatomegaly
Clinical Features and Complications of β-thalassaemia Major
 - Pallor
 - Jaundice
 - Bossing of the skull
Splenomegaly and hepatomegaly
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
splenomegaly, hepatomegaly
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Splenomegaly > 90% • Hepatomegaly
Cardiac Amyloid - Diagnosis, Signs, Symptoms and Management

Clinical Presentation
- exertional dyspnea
- peripheral edema
- exertional syncope
- peripheral
Kussmaul sign - hepatomegaly
The infant with tachypnea or wheeze - Clinical Conditions to Consider
 - Bronchiolitis 
 - Pneumonia
heart murmur, hepatomegaly
Acute Schistosomiasis: Katayama Fever
 • Most common in travelers and children
 • "Swimmers Itch" in the
Hepatomegaly and