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diagnosis differential management allergy classification anesthesia anesthesiology checklist criticalcare hematology physicalexam pulmonary shock workup antibiotics cardiology intraoperative overview signs symptoms
Stridor - Differential Diagnosis Framework: High-pitched, variable respiratory sound ETIOLOGIES: Infectious: • Retropharyngeal abscess • Acute epiglottitis • Peritonsillar
Allergic/Immune: • Anaphylaxis ... • Hereditary ... angioedema Congenital ... malformations • Anaphylaxis ... differential #diagnosis #causes
Facial Swelling from Hereditary Angioedema on Physical Examination 19 year old Hereditary Angioedema (HAE) patient from Turkey.
Swelling from Hereditary ... Angioedema on Physical ... 19 year old Hereditary ... Angioedema (HAE ... #Angioedema #clinical
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 Tranexamic Acid - Indications and Pharmacology Pharmacokinetics: • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
swelling in w/ hereditary ... angioedema) • ... : Urine Common Uses ... rapid injection; Nausea ... Hypersensitivity & anaphylaxis
Angioedema - Classification Diagnosis and Treatment Types of Angioedema: • Acute allergic angioedema - Usually occurs with
Angioedema - Classification ... Acute allergic angioedema ... urticaria • Hereditary ... angioedema - Rare ... cell-mediated in > 90% of cases
Clinical manifestations of anaphylaxis. Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache Angioedema: Lips, tongue, orbit,
Clinical manifestations ... of anaphylaxis. ... doom. headache Angioedema ... arrest GI (>40%): Nausea ... incontinence #anaphylaxis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... deposition disease, hereditary ... angioedema A -
Manifestations of Anaphylaxis by Body System Dermatologic/mucosal - Eyes: periorbital swelling/erythema, injected conjunctiva, tears - Oral mucosa:
Manifestations of Anaphylaxis ... - Oral mucosa: angioedema ... piloerection, angioedema ... Gastrointestinal - Nausea ... Signs #Symptoms #Anaphylaxis
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 Causes of Angioedema: Differential Diagnosis Framework Mast-cell mediated: • IgE dependent allergic reactions: Food, Drugs, Latex, Stings
Causes of Angioedema ... mediated: • ACEi • Hereditary ... inhibitor deficiency (hereditary ... angioedema) • ... Differential #Diagnosis #Causes
Intraoperative Anaphylaxis - Guidelines for Crises in Anaesthesia • Unexplained hypotension • Unexplained bronchospasm (wheeze may be absent
Intraoperative Anaphylaxis ... bradycardia • Angioedema ... arrest where other causes ... arrest trolley, anaphylaxis ... an appropriate critical
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
decades of life Causes ... and clinical associations ... Female predominance Anaphylaxis ... lesions - Wheals/angioedema ... fever, fatigue, Nausea
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