9 results
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
Diagnosis and Treatment ... urticaria • Hereditary ... • Bradykinin ... Treatment of Angioedema ... • Bradykinin-mediated
Angioedema - Diagnostic Algorithm

#Diagnosis #Allergy #Angioedema #Hereditary #Acquired #C1Inhibitor #Bradykinin #Algorithm
Angioedema - Diagnostic ... Diagnosis #Allergy #Angioedema ... #Hereditary #Acquired ... #C1Inhibitor #Bradykinin
Bradykinin-mediated Angioedema
Clinical features: Submucosal oedema (face, extremity, genitalia), Laryngeal dyspnea (25% of deaths), Recurrent attacks of
Angioedema Clinical ... pain Types: • Hereditary ... ineffectiveness • Specific treatment ... #mediated #Angioedema ... diagnosis #management #treatment
Stridor - Differential Diagnosis Framework:
High-pitched, variable respiratory sound

ETIOLOGIES:
Infectious:
 • Retropharyngeal abscess
 • Acute epiglottitis
 • Peritonsillar
Allergic/Immune: • Anaphylaxis ... • Hereditary ... angioedema Congenital ... malformations • Anaphylaxis ... Tracheal stenosis • Anaphylaxis
Causes of Angioedema: Differential Diagnosis Framework
Mast-cell mediated:
 • IgE dependent allergic reactions: Food, Drugs, Latex, Stings
Causes of Angioedema ... NSAlDs, Aspirin Bradykinin ... mediated: • ACEi • Hereditary ... inhibitor deficiency (hereditary ... angioedema) •
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
swelling in w/ hereditary ... angioedema) • ... Hypersensitivity & anaphylaxis
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Female predominance Anaphylaxis ... lesions - Wheals/angioedema ... #rheumatology #comparison
Intraoperative Anaphylaxis - Guidelines for Crises in Anaesthesia
• Unexplained hypotension
• Unexplained bronchospasm (wheeze may be absent
Intraoperative Anaphylaxis ... bradycardia • Angioedema ... arrest trolley, anaphylaxis ... treatment pack ... require prolonged treatment
PEN-FAST Penicillin Allergy Risk Score
PEN - Penicillin allergy reported by patient
F - Five years or less
- 2 points A - Anaphylaxis ... or angioedema OR ... - 2 points T - Treatment