13 results
Stridor - Differential Diagnosis Framework:
High-pitched, variable respiratory sound

ETIOLOGIES:
Infectious:
 • Retropharyngeal abscess
 • Acute epiglottitis
 • Peritonsillar
Allergic/Immune: • Anaphylaxis ... • Hereditary ... angioedema Congenital ... malformations • Anaphylaxis ... differential #diagnosis #causes
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
swelling in w/ hereditary ... angioedema) • ... : Urine Common Uses ... rapid injection; Nausea ... Hypersensitivity & anaphylaxis
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
Angioedema - Classification ... Acute allergic angioedema ... urticaria • Hereditary ... angioedema - Rare ... cell-mediated in > 90% of cases
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... deposition disease, hereditary ... angioedema A -
Clinical manifestations of anaphylaxis. 
Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache
Angioedema: Lips, tongue, orbit,
manifestations of anaphylaxis ... doom. headache Angioedema ... arrest GI (>40%): Nausea ... incontinence #anaphylaxis
Manifestations of Anaphylaxis by Body System

Dermatologic/mucosal

 - Eyes: periorbital swelling/erythema, injected conjunctiva, tears

 - Oral mucosa:
Manifestations of Anaphylaxis ... - Oral mucosa: angioedema ... piloerection, angioedema ... Gastrointestinal - Nausea ... Signs #Symptoms #Anaphylaxis
Causes of Angioedema: Differential Diagnosis Framework
Mast-cell mediated:
 • IgE dependent allergic reactions: Food, Drugs, Latex, Stings
Causes of Angioedema ... mediated: • ACEi • Hereditary ... inhibitor deficiency (hereditary ... angioedema) • ... Differential #Diagnosis #Causes
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
decades of life Causes ... Female predominance Anaphylaxis ... lesions - Wheals/angioedema ... fever, fatigue, Nausea ... #rheumatology #comparison
Intraoperative Anaphylaxis - Guidelines for Crises in Anaesthesia
• Unexplained hypotension
• Unexplained bronchospasm (wheeze may be absent
Intraoperative Anaphylaxis ... bradycardia • Angioedema ... arrest where other causes ... arrest trolley, anaphylaxis ... anaesthesia #Anaphylaxis
Acute and Chronic Causes of Dyspnea - Differential Diagnosis
Pulmonary/Chest Wall:
 • Acute: Trauma, COPD exacerbation, Asthma
Acute and Chronic Causes ... Neck: • Acute: Angioedema ... , Anaphylaxis, Infection ... Acute #Chronic #Causes