2308 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... - Differential ... Defects • Hereditary ... spherocytosis • Hereditary ... Extravascular #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... - Differential ... Diagnosis Algorithm Hereditary ... → Hereditary spherocytosis ... #Anemia #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... defects (e.g. hereditary ... Extravascular #Causes #differential
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... membrane disorder (hereditary ... spherocytosis, hereditary ... #Anemia #Differential
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Spherocytes - Hereditary ... spherocytosis, Hemolytic ... Elliptocytes - Hereditary ... Schistocytes - Hemolytic ... key #diagnosis #differential
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... drugs Elliptocyte: Hereditary ... anemia Spherocyte: Hereditary ... Cold autoimmune hemolytic ... RBC #Morphology #differential
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Hereditary spherocytosis ... udaygulati #Hemolytic ... #Anemia #Differential
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
production (eg, hemolytic ... anemias, hemolytic ... bilirubin) • Hereditary ... #unconjugated #differential
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... • Metabolic/Hereditary ... Bilirubin: RBC (hemolysis ... LDH: Heart, RBC (hemolysis ... injury #hepatitis #differential
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
with or without hereditary ... Schistosomiasis - Chronic hemolytic ... Classification #Diagnosis #Differential