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diagnosis hemolytic algorithm monoclonal pancytopenia treatment workup aiha causes hemeonc hemolysis hodgkins lymphoma mgus systemic acquired agglutinin antibody atlas bandemia
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Differential Diagnosis ... Cold Agglutinin Disease ... Diagnosis #Table #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... • Blood smear: Differential ... Warm #Antibody #Autoimmune ... #diagnosis #management ... #treatment #rheumatology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
anemia (sometimes ... spherocytosis, Autoimmune ... Agglutinate: Cold autoimmune ... RBC #Morphology #differential ... #diagnosis #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... - Extrinsic: Autoimmune ... Non-megaloblastic: Liver disease ... MCV #Algorithm #Differential ... #Diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Congenital Diseases ... deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... #Diagnosis #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
B12, Folate • Hormone ... Chronic kidney disease ... • Hemolysis: Autoimmune ... Production #Index #hematology ... #anemia #differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... elliptocytosis, autoimmune ... #Differential # ... Algorithm #workup #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Autoimmune Mediated ... Autoimmune condition ... Acquired Aplastic Anemia ... Metastatic Disease ... Diagnosis #Algorithm #Hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... esp if severe disease ... AIHA #Treatment #management ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... idiopathic) - Autoimmune ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
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