13 results
diagnosis hematology algorithm causes hemolysis extravascular intravascular management mgus workup agglutinin aplastic atlas bloodcell classification diffuse disease gammopathies gammopathy hodgkins
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... malignancies - B-cell ... younger pts) Differential ... #anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... (e.g. primary cold ... Hemoglobinopathies (e.g. sickle cell ... Extravascular #Causes #differential ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Warm AIHA • Cold ... • Sickle cell ... anemia • ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Agglutinate: Cold ... autoimmune hemolytic ... cold hemoglobinuria ... RBC #Morphology #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider sickle cell ... Agglutination - Cold ... #Anemia #Differential
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Lymphoblastic Leukemia (Pancytopenia ... Lymphocytes) - Monoclonal ... Reed-Sternberg Cells ... Algorithm #Causes #Hematology ... #Oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Gammopathies C - HyperCalcemia ... 40 ml/min A - Anemia ... marrow plasma cell ... • CML, B and T cell ... #oncology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA, Cold ... Defects: Sickle cell ... anemia, Thalassemias ... Diagnosis #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
No evidence of anemia ... damage, such as hyperCalcemia ... insufficiency, Anemia ... #Significance #hematology ... #diagnosis #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
bone marrow + pancytopenia ... Anticonvulsants - Gold ... number of CD34+ cells ... • Peripheral Pancytopenia ... #oncology #hematology
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