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differential autoantibodies table antinuclear management systemic algorithm antibody antineutrophil aortitis cryoglobulins dermatology glomerulonephritis nonpalpable palpable progressive purpura rapidly rpgn size
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... c-ANCA - Vasculitis ... - Vasculitis, e.g ... #diseases #diagnosis ... #table #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... erythematosus ... Vasculitis: • ... Renal-limited vasculitis ... #diagnosis #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... ANA (anti-nuclear ... Vasculitis: P-ANCA ... #diagnosis #associations
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... Vasculitis: + MPO-ANCA ... , and SLE) • Urinalysis ... #rheumatology # ... classification
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Vasculitis Vasculitis ... small vessels - ANCA-associated ... - systemic lupus ... erythematosus ... #Diagnosis #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
vasculitis, rheumatoid ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... • (-) ANA + (+ ... #Diagnosis #Rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
(C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA, ... Glomerulonephritis #Vasculitis ... #algorithm #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... Nodosa (PAN), ANCA ... associated vasculitis ... erythematosus ( ... #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
DDX: • ANCA (Antineutrophil ... • IgA vasculitis ... • Vasculitis ... #rheumatology # ... vasculitis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Leukocytoclastic vasculitis ... • Ig A vasculitis ... (MIXED) • ANCA ... HCV, HBV Not Vasculitis ... #hematology #rheumatology
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