10 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Diagnosis Algorithm ... Warm AIHA • Cold ... perfringens - Complement-Mediated ... • Cold AIHA ... #Causes #Hematology
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing ... Intravascular ... vs Extravascular ... Anemia #Laboratory #Testing ... workup #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
- Intravascular ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... #Hemolytic #Intravascular ... differential #diagnosis #hematology
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Warm vs Cold Autoimmune ... Mechanism: IgG and Complement-mediated ... Mechanism: IgM and Complement-mediated ... BostonChiefs #Warm #Cold ... #Anemia #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Positive Coombs testing ... post infectious setting ... temperatures by fixing complement ... the RBCs causing intravascular ... #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold ... Differential #Diagnosis #Algorithm ... #workup #hematology ... #testing
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
microangiopathic hemolytic ... Microangiopathic hemolytic ... as disseminated intravascular ... coagulation and other testing ... #anemia #Hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Diagnosis for Hemolytic ... • AIHA: warm, cold ... IVIG infusion Intravascular ... udaygulati #Hemolytic ... classification #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

 • Blood loss:
Differential Diagnosis Algorithm ... • Iron loss: Intravascular ... ) hemolysis, Intensive ... Differential #Diagnosis #Algorithm ... #ferritin #hematology
Complement Deficiency Testing Algorithm
 • Normal CH50 and AH50 AND High suspicion for complement deficiency
 •
Complement Deficiency ... Testing Algorithm ... suspicion for complement ... #Deficiency #Testing ... #Algorithm #hematology