19 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... antibiody -> Immune Complex ... Formation - Complement ... > Incr Immune Complex ... Pathophysiology #Rheumatology
Algorithm for the differentiation between simple and complex febrile seizures. Guidelines for evaluation of each. #Diagnosis
Algorithm for the ... between simple and complex ... FebrileSeizure #Fever ... #Workup #Simple ... #Complex
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
immunofluorescence Immune Complex ... staining): • Low Complement ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm ... #rheumatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Differential Diagnosis Algorithm ... perfringens - Complement-Mediated ... Drug-induced immune-complex ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Constitutional domain: Fever ... pericarditis • Hematologic ... anticoagulant • Complement ... #EULARACR #Classification
Fever of Unknown Origin (FUO) - Further Workup

 • CNS symptoms? Get an LP and imaging
Fever of Unknown ... FUO) - Further Workup ... Returning Traveler’ algorithm ... values supporting hematologic ... UnknownOrigin #workup
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Anaphylaxis, Hay fever ... Antigen-antibody complex ... Antigen-antibody complexes ... they activate complement ... allergy #table #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tracts Immune Complex ... Coronary arteries - Fever ... Vasculitis: • Fevers ... against MPO • Complement ... #classification
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
, seasonal hay fever ... antigen, leading to complement ... Antigen-antibody complexes ... Complement activation ... Hypersensitivity #Types #Classification
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... bartonella (oroya fever ... Differential #Diagnosis #Algorithm ... #workup #hematology